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KMID : 0615720150320030083
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Jouranl of Korean Acupuncture and Moxibustion society
2015 Volume.32 No. 3 p.83 ~ p.93
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Effects of Acupuncture at SP6 on Reflux Esophagitis in Rats
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Lee Yun-Kyu
Rho Sung-Soo
Kim Jae-Soo
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Abstract
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Objectives: The purpose of this study was to evaluate whether acupuncture at SP6 attenuates esophageal inflammation on refluxed-induced esophagitis.
Methods: Acupuncture at SP6 was stimulated by acupuncture torsion technique for 30 seconds four times every hour after an operation induced reflux esophagitis(RE), and its effects were assessed in comparison with RE rats without acupuncture, and normal rats.
Results: SP6 acupuncture stimulation markedly ameliorated mucosal damage in the histological evaluation. Reflux-induced esophagitis rats exhibited the down-regulation of antioxidant-related protein expression levels such as heme oxygenase-1(HO-1) in the esophagitis; however, the associated levels with SP6 acupuncture stimulation were significantly higher than those in RE rats without acupuncture stimulation. Moreover, SP6 acupuncture stimulation significantly reduced the expression of inflammatory proteins through mitogen-activated protein kinase(MAPK)- related signaling pathways. The increased protein expressions of inflammatory mediators, cyclooxygenase-2(COX-2) and inducible nitric oxide synthase(iNOS), by nuclear factor-kappa B(NF-kB) activation were significantly suppressed through SP6 acupuncture stimulation.
Conclusions: Our findings support the therapeutic evidence for SP6 acupuncture stimulation alleviating the development of esophagitis via regulating inflammation through the activation of the antioxidant pathway.
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KEYWORD
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SP6, Gastroesophageal reflux disease(GERD), Reflux esophagitis, Anti-inflammatory, Antioxidation
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